News for the Multiple Sclerosis Community

MS and HHV-6A virus

A recent piece of research has suggested a link between the HHV-6A virus and MS. Given that a number of researchers have sugggested a link between MS and a virus (e.g. EBV) would erradicating the virus from our system solve the problem? Is this feasible?

You can suppress a virus, but it never leaves you. Ask anyone who has herpes simplex. I think the regeneration of demyelinated areas is more feasible.
art's picture
That's not true for all viruses. You got over that cold you had last winter, right?
In my MSNews interview with Steve Jacobson of the NIH, he mentions a few drugs (foscarnet, valganciclovir) that may be effective against HHV-6 and notes that a clinical trial of anti-HHV6 drugs would help shed light on the involvement of this virus in MS. Here's an overview of some antiviral drugs that may be effective against HHV-6. And I should also mention the HHV-6 Foundation which promotes scientific research specifically on this virus.

HHV-6 would be difficult to totally eradicate from the body because it persists in a variety of cells and can assume a dormant state which keeps it "hidden" from the immune system. However, the goal may not be to eradicate the virus but just to suppress its activation and replication, which is much more feasible.

By the way, the measles theory has been out there for a long time. I have a book which talks quite tecnically about the virus and MS -I think its from the 80's.
This process described is very similar to the chicken pox virus which can later cause shingles. a trigger of some sort causes the shingles which is a new manifestation of chicken pox. I wonder if the patients who have now been vacinated for chicken pox will ever develop singles or if they are immune to it also.