Oral Inosine found to reduce relapse rate and EDSS progression

Based on earlier papers on this subject, I contacted Dr. Sergei Spitson at the Thomas Jefferson University, who had published results of a limited trial and done research on Inosine. He recommended 2-3 grams/day (you can buy 1 gram pills for about $17/100 ct at healthnut warehouse). I took 3 grams/day but was unable to raise my UA levels significantly. One should also be cautioned that if you try this, make sure you get your UA levels monitored as you can develop gout and/or kidney stones as side affects.

I have had Primary Progressive MS for 20 years. It has been slow but steady with 0 relapses. I was stong enough at 34, no one could tell I was afflicted for ten years. The ABC drugs did nothing. Novantrone zilch. I was so heat sensitive, I had to leave the factory early. Which further perpetuated the myth among my fellow diemakers. I was pulling a scam.
Chapter 2
25 years ago I began to have kidney stones. The analysis of the final nine, uric acid. I had a kidney cat scan done. I am filled with them. They are beginning to fuse together. The last one was so large it wouldn't even start down the uretha. It just wedged like a cork. The ensueing kidney infection nearly killed me. I am currently an MS tripalegic. Not from complications, just my old MS companion.

It seems that this would be a big deal, but, the study population was quite small and it's not very encouraging to see that the -amount- of improvement has not been noted in the abstract. Isn't that the most important fact?

I have confirmed MS!! I had Gout last year!! I would have rather had a broken toe! Many of the meds MS people take are diuretics and can help to promote Gout but with good health it doesn't happen. My issue was I was still eating a bunch of crap still, and it just compounded the issue. I health-ed up a bit and it hasn't been back so I figure it works. They say the chances are real good you will get it back within a year and I haven't.

According to new research here, even slightly elevated uric acid levels can lead to impaired thinking.

Great choice, huh?

To the Gentleman with the Gout-
we discovered after my husband had several attacks of the gout, that cherry juice is an excellent preventative- the attacks are terrible as you know, so you might try drinking this on a daily basis to ward off the trouble. not only is it painful but it would eventually affect the heart. This made us take it very seriously. A good idea to limit meat also.

Uric Acid is a natural scavenger of peroxynitrite. Peroxynitrite is a very damaging free radical. Inosine degrades into uric acid and raises ATP somewhat. I took Inosine for five years to control MS fatigue and heat sensativity with great success. Initially I took 3 grams a day. I tested my blood monthly for two years to monitor uric acid levels. I found that 500 mg twice daily was sustainable with a target uric acid level of 8. MS patients tend to run low uric acid, women tend to run lower than men in the general population. I have found that Inosine is a great tool to control symptoms in many MS patients. Patients with stable MS were helped less than those with more activity. I no longer need to take Inosine. My ms symptoms remained in check but lesions continued to advance.

Two years ago I tried a new and untested approach. I felt that Nanobacterium sanguineum (NB)played a role in MS. I tested high positive. An MRI established a baseline lesion record then I treated for NB for one year followed by a second MRI. There was no change in my lesion load where there had been increasing numbers before. My symptoms became absent and remain so. I continue to supress NB and remain MS "free". Treatment is cheep with no untward side effects. I take no other medications.

I recommend Inosine to control symptoms but urge testing and treating NB to arrest MS.

Hi Frank76,
I refer you to the book "The Calcium Bomb: The Nanobacteria Link to Heart Diease & Cancer" by Douglas Mulhall & Katja Hansen ISBN 1-59411-101-4. Also check out http://www.nanobaclabs.com/ . Over two years ago I became aware of Nanobacterium saguineum (NB) now refered to as Calcifying Nano-particles (CNP). After reading the book I felt there is a conection to my MS. I contacted Nanobac labs to learn that no one with MS had been treated. I tested high positive and began a year long treatment with a baseline MRI and year end MRI to compare. The side effects were nominal and comparable to treatment of other dieases involving NB. The MRI studies indicated no advancement of my lesions. In fact they were "identical". My MS symtoms stemming from an imbalanced endocrine system were arrested. All of my other symptoms have steadily improved. I remain exacerbation free. I take no other medications. I continue to supress NB and feel better than normal. A friend with MS has begun this treatment a few months ago with more dramatic results than mine. She is more advanced than I. The treatment involves taking a suppository of 1200 mg EDTA (disodium calcium), 500 mg tetracycline HCI, and suppliments to support the treatment and tissue cell and blood vessal health. The suppliments contain vitamins C, Niacin, B-6, Folate and coenzyme Q-10. Also EDTA, L-lysine, L-arginine, L-ornithine, bromilain, trypin, grape seed extract, hawthorn berry and papain are in this suppliment. The cost is about $10 a day for the initial treatment and a few dollars a day for maintenance. I take these all before bed. To date there has not been any scientific study on the conection between NB and MS. I believe that MS is NOT an autoimmune disease. Rather, I believe that the immune system is performing correctly, trying to remove NB which it cannot. Sustained inflamation gives the appearance of a myelin attack. The body is removing myelin to expose new unNBdamaged calcium channels in order to maintain regulation of the sodium potassium pump and thus electrical signal in the nerve, relapse and remission. Finally, enough myelin has been removed that the signal becomes too inefficient and you have progession. Also many of our symptoms are not due to our lesions. A poorly functioning edocrine system, due to NB, is producing imbalances which present as MS symptoms. I could go on. You ask if there is a scientific reference to a conection. Not yet. Cures or treatments begin with some knowledge, obsevation, recognition or even an "AHA". I suggest that we test a small but significant group of MSers for the presence of NB. If the results show that it exceeds significantly above the 15%, or so, average in the general population then a blind study would be in order, and so on. Unfortunately, or not, there is not a patent readily here. The meds are off the shelf so money to study this is lacking. NASA is studying NB in kidney stones. Heart diease and cancer are being studied too. Lets put MS in the mix. If I am wrong, ok. If I am right or partly right, it's only good. It's not hard to find out. Remember stomach ulcers? Too much acid, right?. No, it took ten years for that Australian Dr to be heard and now stomach ulcers are treated by antibiotics.
Frank76, do you have MS? If so, I think this makes some sense to you. I am ready to explain and defend this. I can fill in detail later if requested. Diet and suppliments are areas I have also studied in my MS. By the way, Inosine helped me greatly but I don't need it now.
Amenities, Scott Farmer

I also have stabilized after being on antibiotics for 2 years (MRI scan same as 2 years ago with cervical spinal lesions less extensive) and one of the antibiotics is doxicycline, a tetracycline. The theory behind my taking antibiotics is to get rid of a persistent infection by chlamydia pneumonia but I wonder if I should be taking more calcium supplements as well. Is that what disodium calcium is?

Alki G,
I am targeting NB.

"...Why do we calcify when our blood calcium level is normal? NB seem to be the only known pathogens to grow a calcified shell when calcium is not plentiful and acidity is neutral. Kajander and his colleagues found that they suck calcium from their surroundings, then combine it with other chemicals and compounds, such as cholesterol or lipids, to secrete biofilm. Ciftcioglu (now on contract with NASA) found that this solidifies into apatite, a calcium compound armor. The capacity to generate such a shell under regular blood-like conditions seems unique to NB. The ability to do that when low and moderate concentrations of calcium are present may explain why we calcify when our calcium blood levels are balanced...Once NB are encased in their shell (of calcium phosphate) they go semidormant... The shells are hard to strip off. It resists heat, radiation, and drugs." (pg 61 Mulhall).

I have experimented with diet for a number of years and the bottom line is that a diet that alkalizes the body controled or reduced my MS symptoms. That means NO SUGAR, learn to like millet and green leafy veges. You heard it all before. But high acid forming foods are avoided, low acid forming foods are subtituted with alkali forming foods when possible and high alkali forming foods are sought out. Before I started the NB treatment I supplimented minerals along with enzymes, vitamins, probiotics, (focused on antioxidants). Calcium needs to be balanced with magnesium in a ratio of 1 to 2 taken with cod liver oil, lemon flavor tastes fine. I was very low in rubidium and supplimented it too. There were the regular minerals we are familiar with but they are too many to discuss here. Now I take a mineral program designed to compliment this thereapy. Also DRINK PLENTY OF WATER (8-10 glasses a day).
EDTA (ethylenediaminetetraacetic acid) is given to patients suffering from heavy metal toxicity. If you have lead poisoning they give you IV EDTA. EDTA is bound atomically with a lighter weight metal for ingestion, in this case disodium calcium. When it encounters a heavier metal it releases the calcium and binds with the heavier. The idea is that EDTA will bind with the calcium phoshate shells, break the armor down and allow the tetracycline to kill the NB inside. EDTA is approved by the FDA as a food additive.

" The treatment has been administered at home once a day by the patient in three parts ( a suppository, an antibiotic, and a neutraceutical... # The suppository contained a base with the calcium dissolving and removing agent EDTA. # The capsule contained tetracycline hydrochloride.. an antibiotic that is effective against NB. # The neutraceutical contained enzymes and amino acids systems to disolve fibroid deposits and soft plaque. It also sustained levels of disodium calcium EDTA.."( pg 94 Mulhall) and a blend of suppliments mentioned earlier above.

I belive that your two years on antibiotics killed new, unarmored NB thereby reducing or eliminating the toxicity of NB biofilm. However, NB that was already armored remained. The three part therapy above is designed to address all stages.

I hope this answers your questions. Pay attention to your MS symtoms relative to barometric pressure levels. A study I did indicated that when the ambient temperature is below the level affecting your MS and the barometric pressure is low, your symptoms are worsened. Conversely, when it is cool and during a high barometric pressure your symptoms will be lessened relative to the low. During hot periods this affect is washed out by the heat effect. Of course there are other factors.

Regards, Scott Farmer.

Alki G,

It looks as though study of antibiotics as a treatment of MS is in the offing. The focus will be the protein binding the inner and outer layers of blood vessels.

Ten plus five used to result in 15. Maybe NB has altered that!

To Anonymous,

Ten plus five still results in fifteen. Arithmatic is safe. MS has an unknown variable. What is the cause(s) and what will "cure" or control it. Consider

100(NB/MS)=100

where 100=wellness, NB is substituted as the cause and treatment, and MS is the disease or condition with an associated treatment. If NB has a role in MS, as NB approaches MS, wellness is the result. To what extent NB is important in MS is yet to be determined. I suggest that it is. We must look before we can see.

At "100" and holding, Scott Farmer.